By Charles A. Nelson, Monica Luciana
The second one variation of a necessary source to the evolving box of developmental cognitive neuroscience, thoroughly revised, with elevated emphasis on social neuroscience, medical problems, and imaging genomics.
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The invention of microRNAs has published an unforeseen and unbelievable extra point of excellent tuning of the genome and the way genes are used time and again in several combos to generate the complexity that underlies for example the mind. because the preliminary stories played in C. elegans, now we have long gone a much technique to start to know how microRNA pathways may have an impression on healthiness and ailment in human.
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Additional resources for Handbook of Developmental Cognitive Neuroscience, 2nd edition (Developmental Cognitive Neuroscience)
At birth the human brain contains on the order of 100 billion neurons (Kandel, Schwartz, and Jessell, 2000). As the newborn brain grows in size and complexity, these neurons undergo dendritic branching and arborization, synaptogenesis, myelination, and ultimately synaptic pruning. Huttenlocher’s pioneering work in the early 1980s charted the time courses of synaptogenesis and synaptic pruning. His series of histological studies demonstrated that synaptic density is high at birth and continues to increase throughout the ﬁrst year of postnatal life, reaching its maximum between 12 and 18 months postnatal.
The distribution of retinal ganglion cells’ axons in their midbrain target (optic tectum or superior colliculus) is a model system in understanding this process (McLaughlin and O’Leary, 2005). 10 and plate 5). Ephrin-A2 and -A5 are expressed in an increasing gradient from the anterior to posterior letourneau: formation of axons and dendrites by developing neurons 17 tectum. EphA receptors bind ephrin-A ligands and trigger decreased Rac1 and Cdc42 activities and increased RhoA activity, stimulating growth cone repulsion.
Dickson, B. , 2002. Molecular mechanisms of axonal guidance. Science 298:1959–1964. Fass, J. , and D. J. Odde, 2003. Tensile force–dependent neurite elicitation via anti-β1 integrin antibody-coated magnetic beads. Biophys. J. 85:623–636. Flanagan, J. , 2006. Neural map speciﬁcation by gradients. Curr. Opin. Neurobiol. 16:59–66. , and P. C. Letourneau, 1998. Localized sources of neurotrophins initiate axon collateral sprouting. J. Neurosci. 18:5403–5414. , and P. C. Letourneau, 1999. Different contributions of microtubule dynamics and transport to the growth of axons and collateral sprouts.
Handbook of Developmental Cognitive Neuroscience, 2nd edition (Developmental Cognitive Neuroscience) by Charles A. Nelson, Monica Luciana