Read e-book online Hair Cell Regeneration, Repair, and Protection (Springer PDF

By Richard J. Salvi, Richard R. Fay

ISBN-10: 0387733639

ISBN-13: 9780387733630

ISBN-10: 0387733647

ISBN-13: 9780387733647

No longer male development baldness, however the lack of sensory hair, is a truly critical subject. Sensory hair cells convert sound and movement into our feel of listening to, circulate, and head place. In mammals, the lack of hair cells is irreversible. Or is it? Hair cells in different vertebrates are able to regenerating and improving partial or whole functionality. This booklet presents a finished survey of the regeneration of sensory hair cells.

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Richard J. Salvi, Richard R. Fay's Hair Cell Regeneration, Repair, and Protection (Springer PDF

Now not male trend baldness, however the lack of sensory hair, is a really critical subject. Sensory hair cells convert sound and movement into our experience of listening to, circulation, and head place. In mammals, the lack of hair cells is irreversible. Or is it? Hair cells in different vertebrates are able to regenerating and getting better partial or entire functionality.

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Neural stem cells have shown therapeutic value in a number of models. For example, intravenous injection of human neural stem cells into a rat model of ischemic stroke led to engraftment of stem in the damaged region, differentiation into neural phenotypes, and improved behavioral performance (Chu et al. 2004). 1 Stem Cells from the Inner Ear There is no evidence for stem cells in the adult mammalian cochlea; however, a limited number of new hair cells have been found in damaged vestibular organs, suggesting the presence of a stem cell pool.

Nat Med 9:1293–1299. Li S, Price SM, Cahill H, Ryugo DK, Shen MM, Xiang M (2002) Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development 129:3523–3532. Liberman MC, Gao J, He DZ, Wu X, Jia S, Zuo J (2002) Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature 419:300–304. Lifshitz J, Furman AC, Altman KW, Saunders JC (2004) Spatial tuning curves along the chick basilar papilla in normal and sound-exposed ears.

Multipotent stem cells from fetal and adult animals have been identified in many different tissues; those from hematopoietic, neural, and mesenchymal sources have been most thoroughly studied. Purified hematopoietic stem cells have been used to repair liver damage; injection of purified hematopoietic stem cells gave rise to new, donor-derived hepatocytes in the liver and restored biochemical function (Lagasse et al. 2000). Multipotent adult progenitor cells derived from a subpopulation of mesenchymal stem cells are extremely plastic.

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Hair Cell Regeneration, Repair, and Protection (Springer Handbook of Auditory Research) by Richard J. Salvi, Richard R. Fay


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