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Archives of Neurology. 2003 Aug;60(8):1119–22. 22. National Institute on Aging, Progress Report on Alzheimer’s Disease 2004-2005. NIH Publication No. 05-5724. Bethesda, MD: National Institute on Aging, 2005. asp 23. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, Hebert LE, Hennekens CH, Taylor JO. Prevalence of Alzheimer’s disease in a community population of older persons: Higher than previously reported. The Journal of the American Medical Association. 1989 Nov 10;262(18):2551–6.

People who suspect they have a rare disease strongly tied to their genetic make-up—for example, if a rare disease runs in their family— may want to ask their health-care providers about genetic testing. Their providers can tell them whether or not the disease can be detected through genetic testing at this time and, if so, what kind of test and follow-up care are needed. What are the new genome scans on the market? In recent years, scientists identified almost all of the genes in humans and the most common variations in many of them.

Given four related lines of evidence, the findings were not a complete surprise. First, more than half the people with Cushing’s disease, in which a disordered adrenal system releases too much cortisol, have depression and anxiety. Second, the “anxious-retarded” subtype of depression is commonly associated with disruption of that same hormonal system. Third, people getting corticosteroid therapy for inflammatory and other disorders have increased mood-related side effects, including anxiety and depression.

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General relativity and gravitation Vol. 12


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