By Toshio Nakanishi, Roger R. Markwald, H.Scott Baldwin, Bradley B. Keller, Deepak Srivastava, Hiroyuki Yamagishi
This quantity makes a speciality of the etiology and morphogenesis of congenital center illnesses. It reports intimately the early improvement and differentiation of the guts, and later morphologic occasions of the cardiovascular approach, masking quite a lot of issues akin to gene capabilities, progress components, transcription components and mobile interactions which are implicated in cardiac morphogenesis and congenital center disorder. This publication additionally provides fresh advances in stem telephone and cellphone sheet tissue engineering applied sciences that have the capability to supply novel in vitro disorder types and to generate regenerative paradigms for cardiac fix and regeneration. this can be definitely the right source for general practitioner scientists and investigators searching for updates on contemporary investigations at the origins of congenital center affliction and capability destiny therapies.
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Additional info for Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology
Moreno-Rodrı´guez, Yukiko Sugi, and Russell A. Norris Abstract In searching for remedial etiologies for congenital heart disease (CHD), we have focused on identifying interactive signaling pathways or “hubs” in which mutations disrupt fundamental cell biological functions in cardiac progenitor cells in a lineage-specific manner. , periostin) and the cytoskeletal regulatory protein, filamin A (FLNA). We discuss them in the context of valve and septal development and the lineages which give origin to their progenitor cells.
Gittenberger de Groot AC, Winter EM, Bartelings MM, et al. The arterial and cardiac epicardium in development, disease and repair. Differentiation. 2012;84:41–53. 7. Zhou B, von Gise GA, Ma Q, et al. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol. 2010;338:251–61. 8. Smith CL, Baek ST, Sung CY, et al. Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling.
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Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology by Toshio Nakanishi, Roger R. Markwald, H.Scott Baldwin, Bradley B. Keller, Deepak Srivastava, Hiroyuki Yamagishi