Nora L. Nock Ph.D. (auth.), Sanford D. Markowitz, Nathan A.'s Energy Balance and Gastrointestinal Cancer PDF

By Nora L. Nock Ph.D. (auth.), Sanford D. Markowitz, Nathan A. Berger (eds.)

ISBN-10: 146142366X

ISBN-13: 9781461423669

The gastrointestinal tune offers one of many distinctive platforms the place a number of malignancies, together with adenocarcinoma of the pancreas, esophagus and colon are each one linked to weight problems. This exact organization is roofed during this quantity of strength stability and melanoma from the epidemiologic, biologic and capability etiologic perspective. the focal point on attainable nutritional contribution in addition to the function of workout in prevention and treatment is gifted in either animal version and sufferer established experiences. designated concentration is supplied additionally at the position of genetic mutations and inflammatory pathways as drivers of those weight problems comparable gastrointestinal malignancies. total, this quantity on power stability and Gastrointestinal Malignancies could be helpful to Epidemiologists, Gastroenterologists and Oncologists, in addition to to scholars and researchers from a number of disciplines drawn to figuring out and disrupting the organization among weight problems and cancer.

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L. Nock 82. Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS (2008) Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803. J Clin Oncol 26:4109–4115 83. McWilliams RR, Matsumoto ME, Burch PA, Kim GP, Halfdanarson TR, de AM, ReidLombardo K, Bamlet WR (2010) Obesity adversely affects survival in pancreatic cancer patients.

3 [173–180]. To date these studies have been limited to individuals of European ancestry. So what candidate genes have been identified through CRC GWAS? Of the 15 SNPs identified to date, 6 map to regions that include TGFb signaling pathway genes, a pathway that previously has been implicated in CRC. These include SMAD7 [174, 179], GREM1 [176], RHPN2, the bone morphogenetic protein genes BMP2 and BMP4 [179], and most recently LAMA5 that is required for the production of noggin, a secreted BMP antagonist [180].

Jiao L, de Berrington GA, Hartge P, Pfeiffer RM, Park Y, Freedman DM, Gail MH, Alavanja MC, Albanes D, Beane Freeman LE, Chow WH, Huang WY, Hayes RB, Hoppin JA, Ji BT, Leitzmann MF, Linet MS, Meinhold CL, Schairer C, Schatzkin A, Virtamo J, Weinstein SJ, Zheng W, Stolzenberg-Solomon RZ (2010) Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts. Cancer Causes Control 21:1305–1314 72. Arslan AA, Helzlsouer KJ, Kooperberg C, Shu XO, Steplowski E, Bueno-de-Mesquita HB, Fuchs CS, Gross MD, Jacobs EJ, Lacroix AZ, Petersen GM, Stolzenberg-Solomon RZ, Zheng W, Albanes D, Amundadottir L, Bamlet WR, Barricarte A, Bingham SA, Boeing H, BoutronRuault MC, Buring JE, Chanock SJ, Clipp S, Gaziano JM, Giovannucci EL, Hankinson SE, Hartge P, Hoover RN, Hunter DJ, Hutchinson A, Jacobs KB, Kraft P, Lynch SM, Manjer J, Manson JE, McTiernan A, McWilliams RR, Mendelsohn JB, Michaud DS, Palli D, Rohan TE, Slimani N, Thomas G, Tjonneland A, Tobias GS, Trichopoulos D, Virtamo J, Wolpin BM, Yu K, Zeleniuch-Jacquotte A, Patel AV (2010) Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).

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Energy Balance and Gastrointestinal Cancer by Nora L. Nock Ph.D. (auth.), Sanford D. Markowitz, Nathan A. Berger (eds.)

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