By Felix Kratz, Peter Senter, Henning Steinhagen
During this first authoritative review on sleek melanoma chemotherapy 121 foreign experts have contributed their event and up to date facts for what's prone to develop into the most excellent within the box.
The authors summarize wisdom received over the last decade, from uncomplicated ideas to profitable functions within the health center, protecting energetic and passive concentrating on innovations in addition to tissue-specific techniques. All present and destiny distinctive supply structures are mentioned, from ligand-based to antibody-based polymer-based platforms, correct as much as micro- and nanoparticulate platforms. a different part covers the supply of nucleic acid therapeutics, equivalent to siRNA, miRNA and antisense nucleotides. In each one case, an outline of the elemental procedure is by means of a dialogue of the newest preclinical and scientific advancements within the box.
by way of advantage of its transparent and didactic constitution, wealthy illustrative fabric and precis chapters, this instruction manual and prepared reference permits the effective move of data among diverse disciplines, from uncomplicated examine to the clinician and vice versa. it really is both compatible for execs, researchers and scholars in clinical oncology and melanoma biology, and is usually first-class for instructing scientific scholars the principles of twenty first century melanoma chemotherapy.Content:
Chapter 1 Limits of traditional melanoma Chemotherapy (pages 1–31): Klaus Mross and Dr. Felix Kratz
Chapter 2 Pathophysiological and Vascular features of good Tumors on the subject of Drug supply (pages 33–64): Peter Vaupel
Chapter three more desirable Permeability and Retention influence on the subject of Tumor concentrating on (pages 65–84): Hiroshi Maeda
Chapter four Pharmacokinetics of Immunoglobulin G and Serum Albumin: impression of the Neonatal Fc Receptor on Drug layout (pages 85–120): Jan Terje Andersen and Inger Sandlie
Chapter five improvement of Cancer?Targeting Ligands and Ligand?Drug Conjugates (pages 121–168): Ruiwu Liu, Kai Xiao, Juntao Luo and equipment S. Lam
Chapter 6 Antibody?Directed Enzyme Prodrug remedy (ADEPT) ? easy ideas and its perform thus far (pages 169–186): Kenneth D. Bagshawe
Chapter 7 Imaging strategies in Drug improvement and scientific perform (pages 187–224): John C. Chang, Sanjiv S. Gambhir and Jurgen okay. Willmann
Chapter eight Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug supply (pages 225–245): Patrick D. Sutphin, Efren J. Flores and Mukesh Harisinghani
Chapter nine Preclinical and scientific Tumor Imaging with SPECT/CT and PET/CT (pages 247–288): Andreas ok. greenback, Florian Gartner, Ambros Beer, Ken Herrmann, Sibylle Ziegler and Markus Schwaiger
Chapter 10 Empowered Antibodies for melanoma treatment (pages 289–323): Stephen C. Alley, Simone Jeger, Robert P. Lyon, Django Sussman and Peter D. Senter
Chapter eleven Mapping obtainable Vascular objectives to Penetrate Organs and reliable Tumors (pages 325–353): Kerri A. Massey and Jan E. Schnitzer
Chapter 12 concerns of Linker applied sciences (pages 355–374): Laurent Ducry
Chapter thirteen Antibody?Maytansinoid Conjugates: From the Bench to the health center (pages 375–394): Hans Erickson
Chapter 14 Calicheamicin Antibody?Drug Conjugates and past (pages 395–410): Puja Sapra, John Dijoseph and Hans?Peter Gerber
Chapter 15 Antibodies for the supply of Radionuclides (pages 411–439): Anna M. Wu
Chapter sixteen Bispecific Antibodies and Immune remedy concentrating on (pages 441–482): Sergej M. Kiprijanov
Chapter 17 layout of Polymer?Drug Conjugates (pages 483–512): Jindrich Kopecek and Pavla Kopeckova
Chapter 18 Dendritic Polymers in Oncology: proof, positive factors, and functions (pages 513–551): Mohiuddin Abdul Quadir, Marcelo Calderon and Rainer Haag
Chapter 19 Site?Specific Prodrug Activation and the idea that of Self?Immolation (pages 553–589): Andre Warnecke
Chapter 20 Ligand?Assisted Vascular focusing on of Polymer Therapeutics (pages 591–625): Anat Eldar?Boock, Dina Polyak and Ronit Satchi?Fainaro
Chapter 21 Drug Conjugates with Poly(Ethylene Glycol) (pages 627–665): Hong Zhao, Lee M. Greenberger and Ivan D. Horak
Chapter 22 Thermo?Responsive Polymers (pages 667–700): Drazen Raucher and Shama Moktan
Chapter 23 Polysaccharide?Based Drug Conjugates for Tumor concentrating on (pages 701–746): Gurusamy Saravanakumar, Jae Hyung Park, Kwangmeyung Kim and Ick Chan Kwon
Chapter 24 Serum Proteins as Drug providers of Anticancer brokers (pages 747–803): Dr. Felix Kratz, Andreas Wunder and Bakheet Elsadek
Chapter 25 destiny traits, demanding situations, and possibilities with Polymer?Based blend treatment in melanoma (pages 805–837): Coralie Deladriere, Rut Lucas and Maria J. Vicent
Chapter 26 scientific adventure with Drug?Polymer Conjugates (pages 839–884): Khalid Abu Ajaj and Dr. Felix Kratz
Chapter 27 evaluation on Nanocarriers as supply platforms (pages 885–905): Haifa Shen, Elvin Blanco, Biana Godin, Rita E. Serda, Agathe okay. Streiff and Mauro Ferrari
Chapter 28 improvement of PEGylated Liposomes (pages 907–949): I. Craig Henderson
Chapter 29 Immunoliposomes (pages 951–987): Vladimir P. Torchilin
Chapter 30 Responsive Liposomes (for good Tumor remedy) (pages 989–1012): Stavroula Sofou
Chapter 31 Nanoscale supply structures for mix Chemotherapy (pages 1013–1050): Barry D. Liboiron, Paul G. Tardi, Troy O. Harasym and Lawrence D. Mayer
Chapter 32 Micellar constructions as Drug supply structures (pages 1051–1069): Nobuhiro Nishiyama, Horacio Cabral and Kazunori Kataoka
Chapter 33 Tailor?Made Hydrogels for Tumor supply (pages 1071–1097): Sungwon Kim and Kinam Park
Chapter 34 pH?Triggered Micelles for Tumor supply (pages 1099–1131): Haiqing Yin and also you Han Bae
Chapter 35 Albumin?Drug Nanoparticles (pages 1133–1161): Neil Desai
Chapter 36 Carbon Nanotubes (pages 1163–1185): David A. Scheinberg, Carlos H. Villa, Freddy Escorcia and Michael R. McDevitt
Chapter 37 Cell?Penetrating Peptides in melanoma concentrating on (pages 1187–1217): Kaido Kurrikoff, Julia Suhorut and ulo Langel
Chapter 38 focusing on to Peptide Receptors (pages 1219–1261): Andrew V. Schally and Gabor Halmos
Chapter 39 Aptamer Conjugates: rising supply structures for particular melanoma treatment (pages 1263–1281): Zeyu Xiao, Jillian Frieder, Benjamin A. Teply and Omid C. Farokhzad
Chapter forty layout and Synthesis of Drug Conjugates of supplementations and progress components (pages 1283–1322): Iontcho R. Vlahov, Paul J. Kleindl and Fei You
Chapter forty-one Drug Conjugates with Polyunsaturated Fatty Acids (pages 1323–1357): Joshua Seitz and Iwao Ojima
Chapter forty two RNA Drug supply techniques (pages 1359–1390): Yuan Zhang and Leaf Huang
Chapter forty three neighborhood Gene supply for treatment of stable Tumors (pages 1391–1413): Wolfgang Walther, Peter M. Schlag and Ulrike Stein
Chapter forty four Viral Vectors for RNA Interference purposes in melanoma learn and treatment (pages 1415–1442): Henry Fechner and Jens Kurreck
Chapter forty five layout of certain Protein pollution (pages 1443–1487): Hendrik Fuchs and Christopher Bachran
Chapter forty six Drug concentrating on to the critical apprehensive approach (pages 1489–1517): Gert Fricker, Anne Mahringer, Melanie Ott and Valeska Reichel
Chapter forty seven Liver Tumor focusing on (pages 1519–1568): Katrin Hochdorffer, Giuseppina Di Stefano, Hiroshi Maeda and Dr. Felix Kratz
Chapter forty eight Photodynamic treatment: Photosensitizer focusing on and supply (pages 1569–1603): Pawel Mroz, Sulbha ok. Sharma, Timur Zhiyentayev, Ying?Ying Huang and Michael R. Hamblin
Chapter forty nine Tumor?Targeting recommendations with Anticancer Platinum Complexes (pages 1605–1629): Markus Galanski and Bernhard okay. Keppler
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Additional info for Drug Delivery in Oncology: From Basic Research to Cancer Therapy
His research encompasses the development and applications of combinatorial chemistry to basic research and drug development. ¨ Langel is a Professor and Chairman at the DepartUlo ment of Neurochemistry, Stockholm University, Sweden. He graduated from Tartu University, Tartu, Estonia, as a Bioorganic Chemist in 1974; he has received his PhD degree twice: in 1980 from Tartu University (Bioorganic Chemistry) and in 1993 from Tartu University/Stockholm University (Biochemistry/Neurochemistry). His professional experience includes a career at Tartu University (from Junior Research Fellow to Associate Professor, Visiting Professor, and Adjunct Professor; 1974 till now); The Scripps Research Institute, La Jolla, CA, USA (Associate Professor and Adjunct Professor; 2000 till now); and Stockholm University (from Research Fellow to Associate Professor, Professor, and Chairman; 1987 till now).
She is a British Chevening Scholar and an Alberta Foundation Researcher, and an author of more than 30 scientiﬁc publications, book chapters, or patents. XLV XLVI List of Contributors Gurusamy Saravanakumar received his Master’s degree in Applied Chemistry from Madurai Kamaraj University, India in 2003 under the guidance of Professor Alagunambi Ramasubbu. He is currently pursuing his PhD degree at Kyung Hee University, South Korea under the guidance of Professor Jae Hyung Park. His primary research interests focus on the development of novel polymeric nanoparticle-based carriers for cancer therapeutics and imaging applications.
A. Paul Krapcho in the synthesis of bis-phenanthroline-based ligands as GQuadruplex-stabilizing agents. After graduating with a BS in Chemistry in 2007, he came to Stony Brook University for its Graduate Chemistry Program. He joined the Ojima Research Laboratory in 2009 for his PhD research. He is currently engaged in the design, synthesis, and biological evaluation of novel taxane-based drug conjugates for tumor-targeted cancer chemotherapy. List of Contributors Peter D. Senter earned his PhD in Chemistry from the University of Illinois in Urbana and then carried out postdoctoral research at the Max Planck Institute in G¨ottingen, Germany.
Drug Delivery in Oncology: From Basic Research to Cancer Therapy by Felix Kratz, Peter Senter, Henning Steinhagen