New PDF release: DNA Methylation, Epigenetics and Metastasis (Cancer

By Manel Esteller

ISBN-10: 1402036418

ISBN-13: 9781402036415

ISBN-10: 1402036426

ISBN-13: 9781402036422

This e-book presents a vast and wealthy define of the epigenetic mechanisms interested by melanoma development and the new release of metastasis. It describes the tumor suppressor genes present process transcriptional silencing through CpG island promoter hypermethylation within the various tumor kinds of the human anatomy and their organization with tumoral behaviour. It additionally offers a complete insightful examine the molecular gamers serious about DNA methylation, histone amendment and chromatin remodelling complexes inflicting epigenetic lesions associated with the metastasic phenotypes. eventually, it explains how epigenetic lesions linked to melanoma spreading will be certain utilizing new and powerful chemotherapy medicines. The booklet is a cutting-edge connection with all medical researchers and clinicians drawn to the knowledge of the organic tactics resulting in tumor dissemination and to people who are willing to translate this information to a greater administration of melanoma sufferers. every one contributor is a consultant of their epigenetic quarter and their joint attempt has created a different view of the DNA methylation, histone and chromatin alterations that outline melanoma metastasis.

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Additional resources for DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment)

Sample text

46. Toyooka K. , Virmani A. , Sathyanarayana U. , Euhus D. , Minna J. D. and Gazdar A. F. Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas. Cancer Res, 2001; 61: 4556-4560. 47. , Eby M. , Huang C. , Sathyanarayana U. , Cunningham H. , Reddy J. , Minna J. , Chaudhary P. M. and Gazdar A. F. Differential inactivation of caspase-8 in lung cancers. Cancer Biol Ther, 2002; 1: 65-69. 48. , Sathyanarayana U. , Huang C. , Minna J. , Chaudhary P. M.

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O'Dorisio M. , Held W. , Cavenee W. K. and Plass C. Aberrant CpGisland methylation has non-random and tumour-type-specific patterns. Nat Genet, 2000; 24: 132-138. 41. , Baylin S. B. and Herman J. G. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res, 1999; 59: 67-70. 41 42. , Corn P. , Baylin S. B. and Herman J. G. A gene hypermethylation profile of human cancer. Cancer Res, 2001; 61: 3225-3229. 43. , Fong K.

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DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment) by Manel Esteller

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