Developmental Immunotoxicology by Steven D. Holladay PDF

By Steven D. Holladay

ISBN-10: 0415284570

ISBN-13: 9780415284578

Regardless of speedily expanding curiosity in developmental immunotoxicology, there isn't but a textbook occupied with this scorching zone of analysis. Developmental Immunotoxicology fills the void with overviews of immune process improvement in experimental animal and human types, and discusses the complicated concerns concerning the evolution of developmental immunology and chance evaluate. this article describes diversified types used to check developmental immunotoxicology and examples of particular developmental immunotoxic brokers, together with therapeutics. The textual content concludes with numerous chapters that describe the function of neuroimmune interactions as they relate to developmental immunotoxicology. utilizing a didactic technique, Developmental Immunotoxicology presents an explanatory evaluate of this state of the art box for toxicologists, immunologists, and developmental biologists. It offers a lucid account of this sector of research-proposing solutions to a few questions and stimulating debate on these questions but to be addressed via the learn neighborhood.

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1980 Nature of the decline in antigen-induced humoral immunity with age. Mech Ageing Dev 14: 165–172. Manley NR and Blackburn CC. 2003. A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from? Curr Opin Immunol 15:225–232. Manz RA, Lohning M, Cassese G, Thiel A, and Radbruch A. 1998. Survival of long-lived plasma cells is independent of antigen. Int Immunol 10:1703–1711. , Dieterlen-Lievre F, Copin SG, and Gaspar ML. 1997. Antigenic phenotype and gene expression pattern of lymphohemopoietic progenitors during early mouse ontogeny.

In limiting dilution assays (LDA), neonatal CD4+ T cells have a lower precursor frequency than adult CD4+ T cells, whereas the precursor frequency of CD8+ T cells in neonates is comparable to the adult level of activity (Deacock et al. 1992). In spite of this, neonatal T cells exhibit lower levels of cytotoxicity in cell-mediated lympholysis assays than adult T cells (West 2002). Presumably, the reduced cytolytic potential, together with a sensitivity of neonatal T cells to chemical immunosuppression, provide an advantageous clinical environment for neonatal heart transplantation.

Eur J Immunol 30:3604–3613. Andrew TA and Owen JJT. 1978. Studies on the earliest sites of B cell differentiation in the mouse embryo. Dev Comp Immunol 2:339–346. Antoine JC, Bleux C, Avrameas S, and Liacopoulos P. 1979. Murine embryonic B lymphocyte development in the placenta. Nature 277:219–221. Auerbach R. 1961. Experimental analysis of the origin of cell types in the development of the mouse thymus. Dev Biol 3:336–354. Bacigalupo A, Frassoni F, and Van Lint MT. 2000. Bone marrow or peripheral blood as a source of stem cells for allogeneic transplants.

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Developmental Immunotoxicology by Steven D. Holladay


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