By Anthony R. Mire-Sluis, Robin Thorpe
This e-book offers complete assurance of the cytokines from a pharmacological strategy. The chapters are awarded in a constant layout permitting effortless cross-reference, with pattern diagrams and a precis desk of crucial evidence for every bankruptcy on the finish of the book.Cytokines is exclusive in stressing cytokine biology and the applying of study info to supply sickness remedy. With 33 exact and up to date chapters approximately person cytokines, this finished reference will offer either clinicians and researchers in immunology and pharmacology with important info. Key gains* Genetic info and sequences* Protein constitution* phone assets and creation* organic job* Cytokine receptor constitution and sign transduction* dialogue of the position of cytokines in sickness and the opportunity of treatment* precis desk of crucial evidence* entire bibliography
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Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes. J. Immunol. 140, 3473. , et al. (1990). Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344, 633. , Calzetti, F. and Bonora, S. (1994). Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharidestimulated human polymorphonuclear leukocytes by delaying mRNA degradation. J. Exp. Med. 179, 1695.
1988) and U937 cells (Knudsen et aL, 1987). , 1988). , 1986). , 1990). , 1990). Also, IL- 1-induced expression of both IL-lcz and IL-lJ3 production was found to be enhanced by PGE 2 in human PBMC (Vannier and DinareUo, 1993). These discrepancies have yet to be explained. Heat shock response inducers downregulate IL-1 expression (Schmidt and Abdulla, 1988). Thus, IL-1 gene transcription is modulated by positive and negative signals and can be modulated by different cytokines, either alone or in combination.
14, 3167. Ghezzi, P. A. (1988). IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma. J. Immunol. 140, 4238. , Kumar, S. and Baglioni, C. (1993). Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C. J. Biol. Chem. 268, 6214. V. and Pennica, D. (1986). Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. J. Immunol. 137, 3644. Guesdon, F. and Saklatvala, J. (1991). Identification of a cytoplasmic protein kinase regulated by IL-1 that phosphorylates the small heat shock protein, hsp27.
Cytokines (Handbook of Immunopharmacology) by Anthony R. Mire-Sluis, Robin Thorpe