By Gerald P. Schatten (Eds.)
This serial offers a accomplished survey of the key subject matters within the box of developmental biology. those volumes are useful to researchers in animal and plant improvement, in addition to to scholars and execs who wish an advent to mobile and molecular mechanisms of improvement. The sequence has lately handed its 30-year mark, making it the longest-running discussion board for modern concerns in developmental biology. quantity eighty presents seven chapters at the most recent examine in developmental biology.
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Extra resources for Current Topics in Developmental Biology
2005). More evidences demonstrating a role for Slits and Robos in angiogenesis come from in vitro studies in which the exposure of Robo‐1‐positive human umbilical vein ECs (HUVEC) to a Slit‐2 source stimulated their chemotaxis. In vivo experiments also supported an attractive role for Slit‐2 on 1. , 2003). , 2003). Additional studies will help to clarify the role of Slit‐2 in developmental and pathological angiogenesis and explain whether Slit‐2 could have opposite eVects (repulsion or attraction) depending on the Robo receptor subtype to which it binds.
Using this animal model, Louissaint et al. (2002) could show that testosterone‐induced angiogenesis as well as neurogenesis were associated with increased VEGF expression within the HVC and BDNF production by ECs. , 2002). , 2002). , 2003). , 2006). , 2004). , 2006). Sun et al. showed that, in VEGF‐B knockout mice, adult neurogenesis is reduced. , 2006). V. Similarities in the Organization of Vascular and Neural Boundaries The physical segregation of distinct diVerentiated cell populations is a requirement for the organization of both the vascular and nervous network.
2001). The apparent contradiction between the eVects of Shh on commissural and retinal axons (attraction vs repulsion, respectively) may be related to the involvement of distinct signaling pathways, resulting in opposite guidance eVects, as we will further discuss Netrins in the following paragraphs. 32 Zacchigna et al. c. Bone Morphogenetic Proteins. , 1996), indicating that additional cues might guide their migration in the dorsal part. The proximity of commissural neurons to the roof plate suggested that the roof plate itself might repel commissural axons.
Current Topics in Developmental Biology by Gerald P. Schatten (Eds.)