By Joan Fujimura
throughout the overdue Nineteen Seventies and Nineteen Eighties, "cancer" underwent a striking transformation. in a single brief decade, what had lengthy been a suite of heterogeneous ailments marked via out of control mobile development turned a sickness of our genes. How this occurred and what it capability is the tale Joan Fujimura tells in a unprecedented within examine the way in which technological know-how works and information is created. A dramatic learn of a brand new species of clinical revolution, this e-book combines a close ethnography of medical proposal, an in-depth account of technology practiced and produced, a historical past of 1 department of technological know-how because it entered the limelight, and a view of the effect of recent genetic applied sciences on technology and society.
The medical company that Fujimura unfolds for us is proto-oncogene melanoma research--the research of these segments of DNA now inspiration to make general cells cancerous. inside this framework, she describes the tactics of information building as a social firm, an never-ending sequence of negotiations within which theories, fabric applied sciences, and practices are co-constructed, included, and refashioned. alongside the best way, Fujimura addresses long-standing questions within the background and philosophy of technology, tradition conception, and sociology of technological know-how: How do scientists create "good" difficulties, experiments, and strategies? What are the cultural, institutional, and fabric applied sciences that experience to be in position for brand spanking new truths and new practices to be triumphant?
Portraying the advance of data as a multidimensional technique carried out via a number of cultures, associations, actors, items, and practices, this booklet disrupts divisions between sociology, heritage, anthropology, and the philosophy of technological know-how, know-how, and medication.
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Extra info for Crafting Science: A Sociohistory of the Quest for the Genetics of Cancer
18 This reification also applies to diagrams, models, drawings, maps, and so forth. 19 Once ideas or theories become resituated, they can be used like technologies and instruments in the production of further representations. The objectified representations can become additional elements in ongoing scientific work. Again, however, the relationship between a representation and its interpretation or use, and therefore its consequences, is not fixed. Representations change depending on who isusingand interpreting them, when, and for which purposes (Duster 1981, 1990; 2 0 Fleck 1979; Knorr-Cetina 1981; Rabinow 1986).
It immediately focused attention on the method of tissue culture as one which could be extremely suitable for the study of growth and, of course, this meant for the study of cancer . . [Tissue culture] was clearly of tremendous importance as a means of investigating, and perhaps eventually combating, the great scourge of cancer. Tissue Culture and Cancer Research were thus early linked together, both practically by the research workers themselves and also in the public mind. (Willmer 1965:3-4) However, Willmer concluded that the popularity of tissue culture as a tool for cancer research in the end both created wasted effort and, on the positive side, aided the development of cell biology but to the detriment of cancer research.
However, after the experimental crosses, only infants with mothers from the high-tumor line developed tumors. Those offspring of fathers from the hightumor line did not develop tumors (Bittner 1 9 3 6 , 1942). To everybody's horror, it turned out that the crosses didn't behave the way they should . . with regard to [mouse] breast cancer anyway. If you had a strain that had a high incidence of breast cancer and a strain with a low incidence, and you crossed those, it should not make a difference whether they were males or females that you put into the cross.
Crafting Science: A Sociohistory of the Quest for the Genetics of Cancer by Joan Fujimura