Clinical trials in neurology : design, conduct, analysis - download pdf or read online

By Bernard Ravina; et al

ISBN-10: 1139032445

ISBN-13: 9781139032445

ISBN-10: 1139379445

ISBN-13: 9781139379441

''Translating laboratory discoveries into winning therapeutics should be tough. medical Trials in Neurology goals to enhance the potency of medical trials and the improvement of interventions to be able to improve the advance of recent remedies for neurologic ailments. It introduces the reader to the main suggestions underpinning trials within the neurosciences. This quantity tackles the demanding situations of developing Read more...

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Blood-brain barrier active elux transporters: ATP-binding cassette gene family. NeuroRx 2005; 2: 86–98. 16. Patel MM, Goyal BR, Bhadada SV, et al. Getting into the brain: approaches to enhance brain drug delivery. CNS Drugs 2009; 23: 35–58. 17. Neuwelt E, Abbott NJ, Abrey L, et al. Strategies to advance translational research into brain barriers. Lancet Neurol 2008; 7: 84–96. Chapter 3: Unique challenges in the development of therapies 18. Rambeck B, Jurgens UH, May TW, et al. Comparison of brain extracellular luid, brain tissue, cerebrospinal luid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy.

Most oten, development teams plan carefully to ensure that the basic exposure requirements set forth by ICH will be met by the time that applications for regulatory approval are submitted and reviewed. hese requirements underscore the need to understand the efective dose range as early as possible during development; failure to do so can lead to signiicant delays while additional patient exposures are accrued. he plan for broadening the understanding of speciic safety issues needs to be articulated at the beginning of late stage clinical trials.

Proc Natl Acad Sci USA 2001; 98: 8850–5. 38. Blennow K, Zetterberg H, Minthon L, et al. Longitudinal stability of CSF biomarkers in Alzheimer’s disease. Neurosc Lett 2007; 419: 18–22. 39. Bacskai BJ, Frosch MP, Freeman SH, et al. Molecular imaging with Pittsburgh Compound B conirmed at autopsy: a case report. Arch Neurol 2007; 64: 431–4. 40. Maeda J, Ji B, Irie T, et al. Longitudinal, quantitative assessment of amyloid, neuroinlammation, and anti-amyloid treatment in a living mouse model of Alzheimer’s disease enabled by positron emission tomography.

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Clinical trials in neurology : design, conduct, analysis by Bernard Ravina; et al

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