By Joel E. Tepper, Leonard L. Gunderson
First Prize winner, Oncology booklet classification, British scientific organization 2012 scientific e-book Competition
• Deepen your wisdom with a complete, medical method of the clinical foundations of radiation oncology and normal oncology in addition to state of the art ideas and modalities.
• enforce a multidisciplinary, "team care" method of delivering complex healing procedures for sufferers, frequently along with clinical oncologists, and surgeons.
• expand your knowing of the fundamental biology of the affliction processes.
• learn the healing administration of particular affliction websites in accordance with single-modality and combined-modality approaches.
• quick and simply locate serious details due to an simply available, full-color layout with over 800 colour figures that truly depict remedy options.
• Get huge multimodality views and designated insights from a various crew of revered editors and participants -many of whom are new to this version - affiliated with associations throughout North the USA and the world over
• entry the absolutely searchable textual content anyplace, every time at www.expertconsult.com, besides references, extra photos and tables, videos and more!
• remain present with entire updates all through that come with a brand new bankruptcy on survivorship matters, and extra videos on remedies reminiscent of prostate and penile melanoma brachytherapy.
• enhance results through supplying the simplest remedy for every sufferer with accelerated assurance of latest modalities and therapy regimens.
• comprehend and conform to the newest staging guidelines.
Drs. Gunderson and Tepper offer you easy access to the entire scientific instruments you must grasp the most recent innovations and modalities in radiation oncology.
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Extra info for Clinical Radiation Oncology (3rd Edition)
60,61 The Puck and Marcus25 acute-dose, x-ray sur vival curve for the human tumor cell line HeLa is shown in Figure 1-8. Following graded x-ray doses, the reproductive integrity of single HeLa cells was measured by their ability to form macroscopic colonies of at least 50 cells (corresponding to approximately six successful postirradiation cell divisions) on Petri dishes. A number of features of this survival curve were of particular interest. First, qualitatively at least, the curve was similar in shape to those previously determined for many microorganisms, being characterized by a shoulder at low doses and a roughly exponential region at high doses.
This occurs because higher linear energy transfer (LET) radiations preferentially decrease or eliminate the shoulder on cell survival curves. Adapted from Nias A: Clinical radiobiology, ed 2, New York, 1988, Churchill Livingstone. 7 Figure 1-19 Increase in the relative biologic effectiveness (RBE) of neutrons relative to x rays when comparing single radiation doses with fractionated treatment. For a given level of cell kill (or other approximately isoeffective endpoint), the more highly fractionated the treatment, the higher the RBE.
However, the knowl edge that tumor hypoxia is a diverse and dynamic process opens up a number of possibilities for the development of novel interventions designed to cope with, or even exploit, hypoxia. Measurement of Hypoxia in Human Tumors Despite prodigious effort directed at understanding tumor hypoxia and developing strategies to combat the problem, it was not until the mid-1980s that these issues could be addressed for human tumors because there was no way to measure hypoxia directly. Before that time, the only way to infer that a human tumor contained treatment-limiting hypoxic cells was by using indirect, nonquantitative methods.
Clinical Radiation Oncology (3rd Edition) by Joel E. Tepper, Leonard L. Gunderson