By Bradley Yoder
Cilia-the tiny hair-like constructions at the floor of cells-have lately been pointed out as enjoying a task in quite a few ailment and developmental problems. Absent or faulty cilia in convinced cells could cause infertility, blindness, kidney affliction, and lung disorder. This quantity offers contemporary findings in cilia learn and present concept at the function of cilia in sickness and developmental abnormalities.
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Extra resources for Ciliary Function in Mammalian Development
2008), which may modulate kinesin-II motor activity via phosphorylation. , 2005; Scholey, 2008). Third, polyglutamylation of axonemal tubulin, mediated by the DYF-1 protein and an associated tubulin polyglutamylase (Ttll6), impairs the velocity of kinesin-2 motors in C.
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2005; Pazour and Rosenbaum, 2002) and will not be dwelled upon extensively here. , 2008; Quarmby and Parker, 2005; Santos and Reiter, 2008) and will therefore not be covered extensively here. , 1993), a process required for the assembly and maintenance of almost all eukaryotic cilia and flagella (Rosenbaum and Witman, 2002). We first provide a general description of IFT, from its initial discovery to the identification and characterization of individual IFT motor subunits and IFT particle polypeptides.
Ciliary Function in Mammalian Development by Bradley Yoder