Download e-book for kindle: Ciliary Function in Mammalian Development by Bradley Yoder

By Bradley Yoder

ISBN-10: 0123744539

ISBN-13: 9780123744531

Cilia-the tiny hair-like constructions at the floor of cells-have lately been pointed out as enjoying a task in quite a few ailment and developmental problems. Absent or faulty cilia in convinced cells could cause infertility, blindness, kidney affliction, and lung disorder. This quantity offers contemporary findings in cilia learn and present concept at the function of cilia in sickness and developmental abnormalities.

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2008), which may modulate kinesin-II motor activity via phosphorylation. , 2005; Scholey, 2008). Third, polyglutamylation of axonemal tubulin, mediated by the DYF-1 protein and an associated tubulin polyglutamylase (Ttll6), impairs the velocity of kinesin-2 motors in C.

Nat. Cell Biol. 7, 517–524. Johnson, U. , and Porter, K. R. (1968). Fine structure of cell division in Chlamydomonas reinhardi. Basal bodies and microtubules. J. Cell Biol. 38, 403–425. Johnson, K. , and Rosenbaum, J. L. (1990). The basal bodies of Chlamydomonas reinhardtii do not contain immunologically detectable DNA. Cell 62, 615–619. , and Willems, T. (2004). The secondary nature of ciliary disorientation in secondary and primary ciliary dyskinesia. Acta Otolaryngol. 124, 527–531. 20 Wallace F.

2005; Pazour and Rosenbaum, 2002) and will not be dwelled upon extensively here. , 2008; Quarmby and Parker, 2005; Santos and Reiter, 2008) and will therefore not be covered extensively here. , 1993), a process required for the assembly and maintenance of almost all eukaryotic cilia and flagella (Rosenbaum and Witman, 2002). We first provide a general description of IFT, from its initial discovery to the identification and characterization of individual IFT motor subunits and IFT particle polypeptides.

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Ciliary Function in Mammalian Development by Bradley Yoder

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