By Ciba Foundation
Chapter 1 Chairman's establishing comments (pages 1–3): C. Rimington
Chapter 2 The Succinate?Glycine Cycle; The function of ??Aminolevulinic Acid in Porphyrin Synthesis (pages 4–26): David Shemin
Chapter three a few houses of ??Aminolaevulic Acid Dehydrase (pages 27–42): ok. D. Gibson
Chapter four The Metabolism of ??Aminolaevulic Acid (pages 43–62): J. J. Scott
Chapter five Haem and Porphyrin Formation from Porphobilinogen Glycine, ??Aminolaevulic Acid and Porphobilinogen (pages 63–71): J. E. Falk
Chapter 6 The function of a few Porphyrins and Porphyrin Precursors within the Biosynthesis of Haem (pages 72–85): Elisabeth I. B. Dresel
Chapter 7 at the Synthes is and Metabolism of C14?Labelled Hematoporphyrin (pages 86–95): Kurt I. Altman, A. ok. Bruce and okay. Salomon
Chapter eight self reliant Biosynthesis of other Haemin Chromoproteins, with precise connection with Cytochrome C; the function of Tissue Organs (pages 96–127): David L. Drabkin
Chapter nine Experimental reviews of Porphyrin Metabolism in Cytochrome C Synthesis (pages 128–142): A. Vannotti
Chapter 10 Porphyrin and Chlorophyll Biosynthesis in Chlorella (pages 143–155): S. Granick
Chapter eleven Heterogeneous Metabolism of Haemoglobins (pages 156–173): G. Schapira, J?C. Dreyfus and J. Kruh
Chapter 12 mobile Formation of Intermediates in the course of Haemoglobin Synthesis (pages 174–184): Bo Thorell
Chapter thirteen Relation of unfastened Erythrocyte Porphyrins to Haemoglobin Biosynthesis (pages 185–195): Leif Eriksen
Chapter 14 stories of a few Liver Heme Proteins and Porphyrins in Experimental Sedormid Porphyria (pages 196–208): Rudi Schmid and Samuel Sciiwartz
Chapter 15 reviews of Porphyrin Synthesis and Interconversion, with targeted connection with convinced eco-friendly Porphyrins in Animals with Experimental Hepatic Porphyria (pages 209–228): Samuel Schwartz and Kojun Ikeda
Chapter sixteen Metabolism of Porphobilinogen and of Porphyrins within the Rabbit (pages 229–245): Alfred Gajdos and Marianne Gajdos?Torok
Chapter 17 Precursors of Porphyrin and Porphobilinogen (pages 246–253): P. Formijne and 9 J. Poulie
Chapter 18 reviews at the Mechanism of Porphyrin Biosynthesis simply by Inhibitors (pages 254–264): W. Stich and P. Decker
Chapter 19 The Formation of Porphyrins via Photosynthetic micro organism (pages 265–284): June Lascelles
Chapter 20 The Synthesis of the Uroporphyrins II and IV (pages 285–302): S. F. MacDonald and Karl?Heinz Michl
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Content material: bankruptcy 1 Chairman's establishing comments (pages 1–3): C. RimingtonChapter 2 The Succinate? Glycine Cycle; The function of ? ?Aminolevulinic Acid in Porphyrin Synthesis (pages 4–26): David SheminChapter three a few homes of ? ?Aminolaevulic Acid Dehydrase (pages 27–42): ok. D. GibsonChapter four The Metabolism of ?
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Extra info for Ciba Foundation Symposium - Porphyrin Biosynthesis and Metabolism
And RUSSELL, C. S. (1953). J. Amer. chem. , 75, 4873. DISCUSSION Gujdos: It is most interesting that Dr. Gibson has found that a great variety of organs are capable of transforming 6-aminolaevulic acid to porphobilinogen in vitro. Our i n vivo experiments also favour this view. I think this is very important in the pathology of porphyria. I am convinced that the disturbances of porphyrin metabolism in this disease cannot be located in a given organ or a given cellular system, but must be explained by a modification of enzymatic systems which are very widely distributed in the whole organism.
SCOTT of ALA by stomach tube. The rats were injected subcutaneously with 2 ml. of physiological saline at hourly intervals for the first eight hours, to replace the water and salt lost in the bile, and to maintain an adequate urine flow. The results are shown in Fig. 3. 3. Excretion of ALA and metabolities, measured simultaneously in the rat. ALA in the urine x-x PBG in the urine n-n Coproporphyrin in the bile Protoporphyrin in the bile. fluoresced deep red, and the biliary porphyrin output did not return to normal until after some time between 12 and 24 hours.
Biochern. , 47,97. , and SCOTT, J. J. (1953). , 172,1093. RADIN,N. , and SHEMIN,D. (1950). J. biol. , 184, 745. RUSSELL, C. , and SHEMIN,D. Unpublished findings. RUSSELL, C. , and SHEMIN,D. (1955). Unpublished findings. SAKAMI, W. (1949). J. biol. , 178,519. , and SHEMIN,D. (1955). J. Amer. chem. ,77,506. ,and SHEMIN,D. (1955). Unpublished. SHEMIN,D. (1948). Cold Spr. Harb. Sym. quant. , 13, 185. , and RUSSELL, C. S. (1954). J. Amer. chem. ,76, 1204. , and KUMIN,S. Red. , 11, 285. , and KUMIN,S.
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