By Dwaine F. Emerich, Reginald L. Dean III, Paul R. Sanberg
Alkermes, Inc., Cambridge, MA. Discusses getting older and Alzheimer's disorder, advancements in animal versions of Parkinson's sickness and Huntington's ailment, advancements for acute neurological stipulations, and advancements in healing brokers. Halftone illustrations. For researchers. DNLM: Alzheimer Disease--physiopathology.
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Finally, as more insight is gained into the nature of the subpopulations of responde and the wide individual variations in most effective dose, one might also expect add tional improvements in treatment responses to be achieved. The fact that few co trolled studies have attempted to account for this variable represents an interesti irony in our efforts to develop effective treatments for AD. Both the initial anim studies (27,28,60), as well as the seminal studies in AD patients (51),noted subgrou of responders and nonresponders, as well as individual variations in peak dos response.
Thus, this discussion is not meantto criticize the approaches, minimize the difficult challenges, or invalidate any individual result obtained. Rather, it isargued that, given the inherent limitations of achieving necessary control in rodent tasks of recent memory, and the differences between themand recent memory paradigms used in higher primates, caution must be exercised when interpreting data from any single rodent paradigm,while replication across many diverse paradigms would help provide some interpretive comfort.
One simply cannot know if whatis being measured is genuine. If perfor mance on the shortest delay condition is not nearly perfect, with gradual decline in accuracy occurring as the retention interval increases, it is very difficult to interpret the task as one that primarily measures recent episodic memory. Thus, one cannot interpre the deficits as primarily due to impairment in recent memory. When necessarycontro conditions are omitted entirely, the data are even less uninterpretable (115-117).
Central Nervous System Diseases by Dwaine F. Emerich, Reginald L. Dean III, Paul R. Sanberg