Klaus Ebnet's Cell Polarity 2: Role in Development and Disease PDF

By Klaus Ebnet

ISBN-10: 3319144650

ISBN-13: 9783319144658

ISBN-10: 3319144669

ISBN-13: 9783319144665

This paintings presents a state-of-the paintings evaluation at the so much proper points of mobilephone polarity.

Volume 2 discusses the physiological and pathophysiological relevance of mobile polarity. It specially specializes in pathophysiological stipulations during which one or a number of features of mobile polarity are impaired, and within which a lack of phone polarity very likely contributes to disorder (e.g. epithelial-to-mesenchymal transition in melanoma, function of polarity proteins in cancer).

Both volumes are meant for professors, workforce leaders and researchers in mobilephone biology in addition to for doctors operating in anatomy, cellphone biology, body structure, pathology and tumor biology.

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Extra resources for Cell Polarity 2: Role in Development and Disease

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Genetics 195:1181–1185 Waddington CH (1942) Canalization of development and the inheritance of acquired characters. Nature 150:563 Wallenfang MR, Seydoux G (2000) Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process. Nature 408:89–92 Wang L, Eckmann CR, Kadyk LC, Wickens M, Kimble J (2002) A regulatory cytoplasmic poly (A) polymerase in Caenorhabditis elegans. Nature 419:312–316 Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ (1996) par-6, a gene involved in the establishment of asymmetry in early C.

Development 126:1–11 Tabuse Y, Izumi Y, Piano F, Kemphues KJ, Miwa J, Ohno S (1998) Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development 125:3607–3614 Tahirovic S, Bradke F (2009) Neuronal polarity. Cold Spring Harb Perspect Biol 1:a001644 Tamburino AM, Ryder SP, Walhout AJM (2013) A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels. G3 (Bethesda) 3:297–304 Tenenhaus C, Schubert C, Seydoux G (1998) Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegans.

Loss of NOS-3 leads to more CUL-2 and thus less PAR-6, which rescues a mutant with reduced PAR-2, potentially by restoring the balance between aPAR and pPAR levels. The other members of the aPAR complex, PKC-3 and PAR-3, are not targets of CUL-2 (Pacquelet et al. 2008), suggesting PAR-6 might be the limiting factor in the anterior. Depletion of CUL-2 alone leads to an extended PAR-2 domain (Liu et al. 2004), which is consistent with an imbalance in anterior-posterior PAR balance but not with the increased PAR-6 levels, as would be expected and would be predicted to expand the PAR-6 domain.

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Cell Polarity 2: Role in Development and Disease by Klaus Ebnet

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