By Hans G. Drexler
This booklet represents a necessary reference guide for the entire well-characterized leukemia-lymphoma telephone traces at present to be had. It offers crucial evidence, utilizing the succinct and straight forward layout that has made the FactsBooks so well liked by scientists and scientific researchers. Introductory chapters supply historical past and standpoint for culturing malignant hematopoietic (blood forming) telephone strains. those chapters are through over four hundred accomplished person entries. each one mobile line access highlights crucial scientific, immunological, genetic, and sensible beneficial properties and contains a entire directory of references.
* the complete spectrum of malignant cellphone traces from all hematopoietic phone lineages
* sister cellphone strains and correct subclones
* scientific facts: sufferer, prognosis, remedy prestige, and specimen source
* authentication of derivation and availability
* cytogenetic karyotype
* translocations and fusion genes
* receptor gene rearrangements and genetic alterations
* mobile cultures facets: institution, medium, doubling time, growth
* cytochemical profile
* cytokine construction and reaction to cytokines
* proto-oncogene and transcription issue expression/alteration
* sensible good points: differentiation induction, heterotransplantability
* exact detailed features
* key references
By Celia Roberts
Because the early 20th century, hormones have in general been understood as 'messengers of sex'. they're obvious as necessary to the improvement and functioning of fit reproductive female and male our bodies; hundreds of thousands take them as medicines within the remedy of fertility, infertility and growing old. even if, in modern society, hormones are either disturbed and nerve-racking; invading our environments and our bodies via plastics, foodstuff and water, environmental estrogens and different chemical compounds, threatening irreversible, inter-generational physically swap. utilizing a variety of assets, from body structure textbooks to well known parenting books and pharmaceutical ads, Celia Roberts analyses the a number of ways that intercourse hormones have come to topic to us this day. Bringing feminist theories of the physique into discussion with technological know-how and know-how reviews, she develops instruments to handle some of the most vital questions dealing with feminism at the present time: how is organic intercourse available?
By Aldo M. Roccaro, Irene M. Ghobrial
This e-book presents a concise evaluate of the state-of-the-art within the biology and therapy of plasma cellphone malignancies, a heterogeneous team of ailments essentially characterised by way of the presence of clonal plasma cells in the bone marrow or extramedullary websites. The plasma telephone dyscrasias investigated comprise monoclonal gammopathy of undetermined importance (MGUS), a number of myeloma, plasmacytoma, immunoglobulin deposition illnesses (primary amyloidosis and systemic gentle and heavy chain deposition diseases), and Waldenström’s macroglobulinemia. on the subject of a number of myeloma, the insurance levels from genomic aberrations and microRNAs to remedy for various sufferer teams, upcoming novel remedies, immunotherapy, and transplantation. The booklet displays the numerous learn advances completed during this box in past times few years, that have greater our realizing of the molecular mechanisms liable for the pathogenesis of plasma phone dyscrasias.
By Terence McLoughlin, Ian Baxter, Nicole Abdul
The Medicine at the Move sequence presents totally versatile entry to topics around the curriculum in a different blend of print and cellular codecs excellent for the busy clinical pupil and junior surgeon. it doesn't matter what your studying type, no matter if you're learning a subject matter for the 1st time or revisiting it in the course of examination training, Medicine at the Move provides you with the help you need.
This cutting edge print and app package deal may help you to hook up with the subjects of orthopaedics and rheumatology, to profit, comprehend, and revel in them, and to cement your wisdom in training for assessments and destiny medical perform. by utilizing this source in print or as an app, you actually will event the chance to profit drugs at the flow.
By Prof. Dr. Med. Erich Schütz (auth.)
Seit R. TIGERSTEDT8 "Physiologie des Kreislaufs" (1921) ist keine zusam menfassende Darstellung der Physiologie des Herzens mehr erschienen. Ein Ver gleich dieses klassischen Werkes mit dem vorliegenden Buch zeigt die gewal tigen Veränderungen, die dieses Gebiet der Physiologie in den letzten Jahrzehnten erfahren, hat. Dabei lag es zugleich in dem mit W. TRENDELENBURG verab redeten Plan, durch dieses Buch auch den Anschluß an die ältere Literatur her zustellen, der in manchen neueren Arbeiten und in manchen Ländern verloren zugehen droht. So stand neben der Darstellung des derzeitigen Standes der Herzphysiologie der didaktische Gesichtspunkt durchaus im Vordergrund, geleitet von der Absicht, dem Leser eine "Brücke" vom studentischen Lehrbuch zu den großen Handbüchern und den Einzelarbeiten der wissenschaftlichen Zeitschriften zu schaffen, ein Gedanke, der dieser ganzen Lehrbuchreihe von vornherein zugrunde lag, damit der Leser wissenschaftlicher Originalarbeiten diese leichter in ihrer Fragestellung und ihren Ergebnissen zu verstehen und einzuordnen vermag. Unter diesem didaktischen Gesichtspunkt mußten viele Einzelarbeiten unzitiert bleiben, um bei der bis zur Unübersehbarkeit ange schwollenen Literatur kein unlesbares Handbuch entstehen zu lassen. So battle das Weglassen das Schwierigste bei der Niederschrift. Unter diesem Gesichts punkt bitte ich jeden Leser um Nachsicht, der seine eigenen Arbeiten nicht genügend berücksichtigt findet. Andererseits vermag bei der Fülle der Literatur auch dem Verfasser manches Wertvolle entgangen sein. Ich darf deshalb beson ders hervorheben, daß ich für die Übermittlung von Hinweisen jeder artwork und die Zusendung von Sonderdrucken jedem sachkundigen Leser besonders dankbar sein werde.
By Eamon Shamil, Praful Ravi, Ashish Chandra
A 27-year-old Ghanaian lady offers within the emergency division with a three-day background of headache, nausea, and imprecise decrease belly soreness. She has no major earlier scientific background, yet is eight-weeks pregnant along with her first baby. She lives in London and lower back from a visit to Ghana two weeks in the past. you've been assigned her preliminary assessment...
100 situations in scientific Pathology provides a hundred medical eventualities mostly noticeable through scientific scholars and junior medical professionals within the emergency division, outpatient health facility, or ordinarily perform during which an realizing of the underlying scientific pathology is relevant to arriving on the right analysis. A succinct precis of the patient's historical past, exam, and preliminary investigations—histopathology, chemical pathology, haematology, microbiology, and scientific immunology as appropriate—is by way of questions about every one case, with specific emphasis at the interpretation of the consequences and the coming at a clinicopathologic analysis. the reply incorporates a specific dialogue on each one subject, offering an important revision relief in addition to a realistic consultant for college kids and junior medical professionals.
Making fast and applicable scientific judgements, and selecting the easiest plan of action to take hence, is among the most crucial and not easy components of teaching to turn into a physician. those true-to-life situations will educate scholars and junior medical professionals to acknowledge vital medical stipulations, to request the best pathological research and properly interpret these effects, and, for that reason, to advance their diagnostic and administration skills.
By Christian Barbato, Francesca Ruberti
In fresh years, figuring out of microRNA (miRNA) biogenesis, the molecular mechanisms wherein miRNAs keep an eye on gene expression, and the useful roles of miRNAs has accelerated. Mapping of fearful method ailments through MicroRNAs presents an up to date evaluation at the functionality of miRNA in neurological ailments in addition to developments in know-how for healing modulation of miRNA activity.
MicroRNAs are small RNA molecules that keep an eye on gene expression post-transcriptionally. A turning out to be physique of proof means that miRNAs are dysregulated in different neurological issues. as well as reviewing common ideas and novel insights on mind functionality on the subject of miRNA, this booklet additionally examines the position of miRNA in:
- Neurological diseases
- Neurodegenerative diseases
- Neuropsychiatric diseases
- Neurodevelopmental diseases
The publication additionally discusses the importance of miRNAs as diagnostic instruments, biomarkers, brokers, and goals within the detection and remedy of neurological illnesses. each one bankruptcy comprises fabric concerning destiny diagnostic and healing advances.
Molecular and mobile neurobiological stories of miRNA-mediated gene silencing within the worried method have opened new frontiers for the improvement of latest diagnostic checks and genetic cures for neurological ailments. masking the entire variety of appropriate recommendations and giving a glance into current and destiny percentages, Mapping of frightened approach illnesses through MicroRNAs is an important state of the art reference for neurologists, neuropathologists, and researchers and practitioners in a variety of comparable fields.
By Donald Metcalf
The colony-stimulating elements (CSFs) are the key regulators within the physique of the construction and task of 2 different types of white blood cells--granulocytes and macrophages. CSFs are utilized by clinicians to regard sufferers with broken immune structures, for instance, because of chemotherapy. This e-book offers a close and updated account of the invention of the CSFs, their constitution, molecular biology and mobile receptors, the biology of the CSFs in vivo and in vitro, and their current and destiny medical functions. Written by way of of the pioneers within the discovery of CSFs, it's a transparent and good illustrated survey of the historical past, present wisdom and destiny instructions of this intriguing box of research, and serves additionally as a advisor to the extra normal components of progress issue and cytokine learn. it's going to turn out a useful evaluate for telephone biologists drawn to how progress components act at the physique, in addition to for clinicians employing the end result of recent biotechnology to more advantageous sufferer care.
By Yoshihisa Kurachi, Lily Yeh Jan, Michel Lazdunski
This ebook is the 1st to target potassium ion channels and covers the hot outstanding growth made in learn on those proteins. Many illnesses are brought on by the abnormalities of potassium ion channels. They contain diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal high blood pressure. Written by way of best scientists within the box, this quantity bargains readers a entire replace of this box within the realizing of the genes, molecular constitution, functionality and ailments of potassium ion channels.
* the 1st complete quantity on potassium ion channels in all elements of genes, molecular constitution, functionality, and diseases
* thoroughly updated information
* Written through prime scientists within the box