Branching Processes Applied to Cell Surface Aggregation - download pdf or read online

By Catherine A. Macken, Alan S. Perelson

ISBN-10: 3540156569

ISBN-13: 9783540156567

ISBN-10: 3642521150

ISBN-13: 9783642521157

Aggregation procedures are studied inside of a couple of varied fields--c- loid chemistry, atmospheric physics, astrophysics, polymer technological know-how, and biology, to call just a couple of. Aggregation professional ces ses contain monomer devices (e. g., organic cells, liquid or colloidal droplets, latex beads, molecules, or perhaps stars) that subscribe to jointly to shape polymers or aggregates. A quantitative thought of aggre- tion used to be first formulated in 1916 via Smoluchowski who proposed that the time e- lution of the combination measurement distribution is ruled by means of the endless approach of differential equations: (1) okay . . c. c. - c okay = 1, 2, . . . okay 1. J 1. J L i+j=k j=l the place c is the focus of k-mers, and aggregates are assumed to shape through ir okay reversible condensation reactions [i-mer ] j-mer -+ (i+j)-mer]. whilst the kernel ok . . may be represented by means of A + B(i+j) + Cij, with A, B, and C consistent; and the in- 1. J itial situation is selected to correspond to a monodisperse resolution (i. e., c (0) = 1 zero, ok > 1), then the Smoluchowski equation could be co' a continuing; and ck(O) solved precisely (Trubnikov, 1971; Drake, 1972; Ernst, Hendriks, and Ziff, 1982; Dongen and Ernst, 1983; Spouge, 1983; Ziff, 1984). For arbitrary okay, the answer ij isn't really identified and in a few ca ses won't even exist.

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1. Note, if i > n, or if n or i are negative, then the binomia1 coef- ficient is defined to be zero. (n)i = (ni -- I1) 1. 13) n The genera1ization of a binomial coefficient to a multinomia1 coefficient is apparent if we write i = (i 1 , i 2 , .... , i f ) and define 2: f k 1, 2, ... 14) 34 When f = 2, the multinomial coefficient reduces C. 1 Let w~~) = ~J to the binomial coefficient. P(a rooted tree contains i particles of type A and j particles of type G, given the root is of type A) w~~) = ~J P(a rooted tree contains i particles of type A and particles of type G, given the root is of type G) and p = P(randomly chosen root is of type A) .

I+j)m ..

No eyelization reaetions oeeur, then one ean eonstruet a system of differential equations for the binding kineties. From these equations, one ean show that at equilibrium (ef. Perelson, 1981; 1984) i = 1, 2, ... ] i=1 J J is the geometrie mean of the equilibrium eonstants for the seeond through the ith step in the easeade of reaetions leading to the formation of an antigen wi th i sites bound. In the following development we assume that independent of i. , 53 Using this model we can explicitly evaluate PAk and P Gl .

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Branching Processes Applied to Cell Surface Aggregation Phenomena by Catherine A. Macken, Alan S. Perelson

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