Get Brain Receptor Methodologies. Part A: General Methods and PDF

By Paul J. Marangos

ISBN-10: 012470350X

ISBN-13: 9780124703506

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Additional resources for Brain Receptor Methodologies. Part A: General Methods and Concepts. Amines and Acetylcholine

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The program allows for formulation and testing of several alternative hypotheses (or models) so that the most appropriate one may be chosen on the basis of an objective, statistically valid criterion, the "extra sum-of-squares" F-test (Draper and Smith, 1981). Several features are included that take advantage of the interactive environment of small microcomputers: parameter values may be changed dynamically, the curve-fitting procedure may be interrupted at any point and a graph of the intermediate results obtained, and parameters may be forced to share a common value or to hold a fixed, predetermined value.

48 Peter J. , Munson, P. , and Rodbard, D. (1978). Am. J. Physiol. 235, E 9 7 - E 1 0 2 . , Hancock, Α. Α . , and Lefkowitz, R. J. (1982). Mol. Pharmacol. 2 1 , 5 - 1 6 . Draper, N . , and Smith, H. (1981). "Applied Regression Analysis," 2nd ed. Wiley, New York. Feldman, Η. Α. (1972). Anal. Biochem. 48, 3 1 7 - 3 3 8 . Hancock, Α. , De Lean, Α . , and Lefkowitz, R. J. (1979). Mol. Pharmacol. 16, 1-9. Harris, D. W . , and Sethy, V. H. (1980). Eur. J. Pharmacol. 66, 1 2 1 - 1 2 3 . Hiller, J. M .

Furthermore, the techniques of computerized optimization of experimental design can lead to new, more economical, and more powerful approaches to the binding experiments themselves. REFERENCES Bard, Y. " Academic Press, New York. Belsley, D. , and Welsch, R. Ε. (1980). " Wiley, New York. Chang, K. , and Cuatrecasas, P. (1981). Proc. Natl. Acad. Sei. A. 78, 4141-4154. Cheng, Y . - C , and Prusoff, W . H. (1973). Biochem. Pharmacol. 22, 3 0 9 9 - 3 1 0 2 . Chrousos, G. P . , Renquist, D . , Brandon, D .

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Brain Receptor Methodologies. Part A: General Methods and Concepts. Amines and Acetylcholine by Paul J. Marangos


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