Brain Oncology Biology, diagnosis and therapy: An by C. C. Tijssen (auth.), M. Chatel, F. Darcel, J. Pecker PDF

By C. C. Tijssen (auth.), M. Chatel, F. Darcel, J. Pecker (eds.)

ISBN-10: 9400933479

ISBN-13: 9789400933477

ISBN-10: 9401080038

ISBN-13: 9789401080033

The foreign assembly on mind Oncology in Rennes used to be organised in honor of Jean Pecker, to pay tribute to his contribution to the advance of neurological sciences and to take inventory of the present country of data on mind tumors, a site during which the function of neurosurgery has been and may stay primordial. in the course of the two-day convention, the most important subject matters of mind oncology stories, either basic and medical, have been tested: oncogenesis, tumoral markers and immunology, metabolic and analysis imaging, prognostic components and healing recommendations. the big quantity and prime quality of participations ended in a certainly man made view of present advances in learn, of which this e-book offers the necessities. now we have tried either to maintain the richness of clinical exchanges which happened and to submit an exceptional many oral and poster communications. The ebook respects the association of convention classes, and therefore displays the significance accorded to glial tumor experiences. this can look disproportionate given their frequency of prevalence in percentage to overall numbers of intracranial tumor procedures, yet their gravity and quasi-total resistance to present healing tools are plentiful justification. additionally, this can be the area during which hopes of development are starting to look, and it really is turning into attainable to envisage therapy in response to lately confirmed basic knowledge.

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Extra resources for Brain Oncology Biology, diagnosis and therapy: An international meeting on brain oncology, Rennes, France, September 4–5, 1986, held under the auspices of the Ministry of National Education, the University of Rennes and the Regional Hospital Rennes

Sample text

The Chronic Myelogenous Leukemia-Specific P210 Protein is the Product of the bcr/abl Hybrid Gene. Science 233: 212-214 (1986). 3. ): Chromosome Translocation and B Cen Neoplasia. Lab Invest 51: 258-267 (1984). 4. ): Chromosomal Characteristics of Neurogenic Tumours in Adults. Hereditas 68: 61-100 (1971). 5. ): G-band Analyses of an Established Cell Line of Human Malignant Glioma. Humangenetik 22: 323-326 (1974). 6. ): Cytogenetical Studies with G-band Technique of Established Cell Lines of Human Malignant Gliomas.

G F A protein is the chief diagnostic antigenic determinant of normal, reactive and neoplastic astrocytes, but it is well-recognized that it may be found in neuroglial tumor cells that are not of astrocytic origin, such as in ependymomas and oligodendrogliomas. Ependymocytes have long been known to contain intracellular glial filaments, which become most prominent when these cells become reactive or neoplastic. Moreover it is apparent that normal ependymal cells will transiently express GFA protein in embryonal development (6).

It has been studied in a number of nerve sheath tumors (24) and in eNS neoplasms (25), especially - but not exclusively - in oligodendrogliomas (8, 25). Although it may be of considerable ancillary help in the elucidation of specific differential diagnostic problems that cannot be resolved by traditional histological techniques, it is clear that the marker is not specific for any particular neural or non-neural cell type. Unlike the reaction obtained with intermediate filament proteins, the cells that are immunopositive for the Leu 7 antibody generally demonstrate the reaction along their cytoplasmic membranes only.

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Brain Oncology Biology, diagnosis and therapy: An international meeting on brain oncology, Rennes, France, September 4–5, 1986, held under the auspices of the Ministry of National Education, the University of Rennes and the Regional Hospital Rennes by C. C. Tijssen (auth.), M. Chatel, F. Darcel, J. Pecker (eds.)


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