By Ryan J. Sullivan
This quantity encompasses a selection of writings from the leaders within the fields of Molecular Biology and cancer examine on the way to start to inform the ever-expanding tale of the latest findings, discoveries, and strength of BRAF-directed objectives in cancer. contemporary examine has proven that BRAF inhibitors are powerful for a quick time period, yet there's little wish that this medications as unmarried brokers will bring about sturdy profit in a majority of sufferers. between scientists and researchers who paintings in drug discovery, there's a lot of curiosity within the improvement of molecularly distinct cancer causing agents. particularly, the identity of a molecular goal, the choice of molecules which successfully inhibit this objective. what's starkly various in regards to the improvement of this category of compounds, besides the fact that, is that the mechanism of motion of those brokers should not as easy as used to be formerly assumed and the mechanisms of resistance that tumor cells hire to steer clear of whole destruction are not like any which were defined earlier than. those discoveries as well as usage of recent molecular biology ideas have ended in a sequence of hypotheses concerning which different different types of molecules might be utilized in mixture with BRAF-inhibitors in hopes of revolutionizing the possibility of therapeutics in melanoma.
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Extra resources for BRAF Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet. 2011;44:165–9. 67. Chin L. The genetics of malignant melanoma: lessons from mouse and man. Nat Rev Cancer. 2003;3:559–70. 68. Koh J, Enders GH, Dynlacht BD, Harlow E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature. 1995;375:506–10. 69. Soufir N, Avril MF, Chompret A, Demenais F, Bombled J, Spatz A, Stoppa-Lyonnet D, Bénard J, Bressac-de Paillerets B.
E. edu Cutaneous Biology Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA © Springer Science+Business Media New York 2015 R. J. 1007/978-1-4939-2143-0_2 25 26 J. A. Lo and D. E. Fisher Melanocytes can produce multiple types of pigment, most obviously dark brown eumelanin and reddish pheomelanin. Pro-pigmentation signaling is initiated by binding of α-melanocyte stimulating hormone (α-MSH) to the melanocortin 1 receptor (MC1R) on the melanocyte cell surface.
J Immunol. 2005;175(9):6169–76. 77. Creagan ET, et al. Three consecutive phase II studies of recombinant interferon alfa-2a in advanced malignant melanoma. Updated analyses. Cancer. 1987;59(3 Suppl):638–46. 78. Kirkwood JM, et al. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol. 1996;14(1):7–17. 79. Kirkwood JM, et al. A pooled analysis of Eastern Cooperative Oncology Group and intergroup trials of adjuvant high-dose interferon for melanoma.
BRAF Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery by Ryan J. Sullivan