New PDF release: Biological Aspects of Suicidal Behavior

By W.P. Kaschka, D. Rujescu, W.F. Gattaz

ISBN-10: 3318055832

ISBN-13: 9783318055832

Suicide is among the most crucial explanations of dying in glossy societies. To strengthen better preventive measures, we need to concentrate on and examine extra approximately its neurobiological foundations. in recent times, the instruments of recent neurosciences have more and more been applied to represent the pathophysiology of advanced human behaviors comparable to suicide. to enhance suicide chance overview and suicide prevention, a greater knowing of its pathophysiology is essential. This comprises learn from a number of disciplines corresponding to neuropsychological, psychosocial and cultural reviews but additionally findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. vital effects have, for instance, been received within the box of gene-environment interplay and suicidal habit. we've simply started to appreciate how early-life adversity might bring up suicide danger by way of epigenetic mechanisms. in response to such insights, novel healing interventions and preventive measures might be built. additionally, a greater knowing of the pathophysiological mechanisms excited by suicidal habit may demonstrate the mechanism of compounds like lithium salts. during this ebook, suicidal habit and its prevention is mentioned by means of foreign specialists within the gentle of the newest effects from a wide spectrum of neurosciences.

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Extra info for Biological Aspects of Suicidal Behavior

Example text

JAMA Psychiatry 2015;72:169–178. 18 Stanley M, Mann JJ: Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1983; 1:214–216. 19 Owen F, Chambers DR, Cooper SJ, Crow TJ, Johnson JA, Lofthouse R, Poulter M: Serotonergic mechanisms in brains of suicide victims. Brain Res 1986; 362: 185–188. 20 Mann JJ, Stanley M, McBride A, McEwen BS: Increased serotonin-2 and β-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry 1986;43: 954–959.

44 Little KY, Clark TB, Ranc J, Duncan GE: β-adrenergic receptor binding in frontal cortex from suicide victims. Biol Psychiatry 1993;34:596–605. 45 DePaermentier F, Cheetham SC, Crompton MR, Katona CLE, Horton RW: Brain α2-adrenoceptor binding sites in antidepressant-treated suicides and controls. Br J Pharmacol 1991;104: 275P. 46 Gross-Isseroff R, Dillon KA, Fieldust SJ, Biegon A: Autoradiographic analysis of α1-noradrenergic receptors in the human brain postmortem effect of suicide. Arch Gen Psychiatry 1990; 47:1049–1053.

42]. Using 3H-dihydroalprenolol (DHA, a β-adrenergic antagonist) as the ligand for β-adrenergic receptor binding, they did not find significant differences in the PFC of suicide victims, although there was a trend towards an increase in β-adrenergic receptor binding. On the other hand, Mann et al. [20] found a significant increase in DHA-specific binding in the frontal cortex of suicide victims, which was further supported by studies of Arango et al. [21] with similar findings. Autoradiographic studies also found a significant increase in β-adrenergic receptors in the gray matter outer layers and in the inner layers of the PFC and temporal cortex of suicide victims.

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Biological Aspects of Suicidal Behavior by W.P. Kaschka, D. Rujescu, W.F. Gattaz


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