By Hiram Gilbert
This moment version maintains to innovatively overview the hardest innovations in biochemistry for max comprehension in a quick time period. in contrast to traditional texts or assessment books that rigidity memorizing evidence, simple strategies stresses the gaining knowledge of of basic thoughts, in order that the reader really comprehends the fabric and feels cozy employing it. Dr. Gilbert makes use of easy, jargon-free language and award-winning instructing suggestions together with algorithms, mnemonics and scientific examples.
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Additional info for Basic concepts in biochemistry: a students survival guide
Information metabolism provides a way to store and retrieve the information that guides the development of cellular structure, communication, and regulation. Like other metabolic pathways, this process is highly regulated. Information is stored by the process of DNA replication and meiosis, in which we form our germ-line cells. These processes are limited to specific portions of the cell cycle. Information is retrieved by the transcription of DNA into RNA and the ultimate translation of the signals in the mRNA into protein.
We’ve just said that charge–charge and hydrogen-bond interactions don’t contribute a lot to the stability of a protein because their interaction in the folded protein simply replaces their individual interaction with water. The same may be said of the interaction between an enzyme and its substrate or one protein and another. However, there is a huge amount of specificity to be gained in these kinds of interactions. For tight binding, the protein and its ligand must be complementary in every way—size, shape, charge, and hydrogen-bond donor and acceptor sites.
Proteins can be associated with either side of the membrane, or they can pass through the membrane using membrane-spanning segments. The functional part of the protein can be on the cytosolic side, the external side, or even in the membrane itself. A common structure for spanning a membrane is an ␣-helix (but there are examples of sheets spanning a membrane). It takes about 20 amino acid residues arranged in a helix to span to a 30 Å hydrophobic interior of the bilayer. Proteins that can be removed from membranes by washing them with salt solutions or low pH solutions (disrupts ionic interactions) are called peripheral membrane proteins.
Basic concepts in biochemistry: a students survival guide by Hiram Gilbert