By Shi Wei
Bone is a dwelling tissue liable to enhance a various array of inflammatory, metabolic, genetic, reactive, circulatory and neoplastic abnormalities. The Atlas of Bone Pathology describes and selectively illustrates the conventional and pathologic stipulations that afflict human bone, focusing seriously on tumor and tumor-like stipulations of bone and their non-neoplastic mimics. Supplemented with radiographic and targeted research pictures, this amazing choice of top of the range electronic photographs reduction carrying on with efforts to acknowledge, comprehend, and thoroughly interpret the sunshine microscopic findings in bone specimens.
Authored via nationally and across the world well-known pathologists, The Atlas of Bone Pathology is a concise and resource for either beginner and pro pathologists alike.
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43 Conventional osteosarcoma. A closer view shows anaplastic tumor cells embedded in a background of osteoid matrix. Note the frequent mitotic activity. Osteosarcoma typically is hypercellular. However, some tumors (or a portion of tumor) may undergo degeneration and appear hypocellular Fig. 44 Conventional osteosarcoma. This section exhibits a lacelike yet thickened osteoid network 47 48 Fig. 45 Conventional osteosarcoma. This osteosarcoma has a more subtle osteoid production. Osteoid is unmineralized bone matrix that typically is homogeneously eosinophic.
This sagittal CT image demonstrates a lytic lesion located within the distal sacrum with cortical destruction and soft tissue extension. There are punctate calcifications within the lesion. The radiographic features of osteoblastoma may be specific but more commonly are not, and they may have features suggestive of a malignancy. The margins may be well-demarcated, poorly defined, or indefinite. An osteoblastoma usually does not induce a marked periosteal reaction, as illustrated in this case 30 Fig.
Osteoid osteoma and osteoblastoma are terms used to describe benign bone-forming tumors with essentially identical histologic features, thus preventing their distinction from one another solely on histomorphologic grounds. They differ in size, anatomic sites, and clinical manifestations. Osteosarcoma is the most common primary malignant tumor of bone, exclusive of hematologic malignancies. Although the tumor may occur at any age with a slightly male predilection, it has a bimodal age distribution, with a propensity to develop predominantly in adolescents and young adults.
Atlas of Bone Pathology by Shi Wei