By Pooria Pasbakhsh; A K Haghi; G E Zaikov
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35 References................................................................................................ 1 INTRODUCTION Currently, the intensive development of biodegradable and biocompatible materials for medical implication provokes comprehensive interdisciplinary studies on biopolymer structures and functions. The wellknown and applicable biodegradable polymers are polylactides (PLAs) and polyglycolides (PGA), and their copolymers, poly-ε-caprolactone, poly(orthoesters), poly-β-malic acid, poly(propylene fumarate), polyalkylcyanoacrylates, polyorthoanhydrides, polyphosphazenes, poly(propylene fumarate), some natural polysaccharides (starch, chitosan, alginates, agarose, dextran, chondroitin sulfate, and hyaluronic acid), and proteins (collagen, silk fibroin, spidroin, fibrin, gelatin, and albumin).
Despite that PHB application in vitro and in vivo has been intensively investigated, the most of the available data are often incomplete and sometimes even contradictory. The presence of conflicting data can be partially explained by the fact that biotechnologically produced PHB with standardized properties is relatively rare and is not readily available due to а wide variety of its biosynthesis sources and different manufacturing processes. Above-mentioned inconsistencies can be explained also by excess applied trend in PHB degradation research.
Very important data that clarifies the tissue response that contributes to biodegradation of PHB was obtained by Lobler. A significant increase of expression of two specific lipases after 7 and 14 days of PHB contact with animal tissues was demonstrated. Moreover, liver-specific genes were induced with similar results. It is striking that pancreatic enzymes are induced in the gastric wall after contact with biomaterials . Saito et al. 5) and kidney esterases with the maximum of activity in neutral media .
Applied research on polymer composites by Pooria Pasbakhsh; A K Haghi; G E Zaikov