Download e-book for kindle: Advances in Radiation Oncology in Lung Cancer by Dusan Milanovic (auth.), Branislav Jeremic (eds.)

By Dusan Milanovic (auth.), Branislav Jeremic (eds.)

ISBN-10: 3642199240

ISBN-13: 9783642199240

Although a long time of laboratory and medical study have ended in incremental development in remedy final result, lung melanoma is still some of the most lethal ailments. within the moment, thoroughly up to date version of this finished booklet, a number of the world’s best lung melanoma experts speak about the hot advances within the radiation oncology of lung melanoma and consider the newest examine findings. the 1st 3 sections hide the elemental technological know-how of lung melanoma, scientific investigations, together with histology and staging, and quite a lot of primary therapy concerns. present remedy concepts for nonsmall telephone and small mobilephone lung melanoma are then defined and evaluated intimately, with due recognition to novel ways that promise extra advancements in end result. a few of the varieties of treatment-related toxicity are mentioned, and caliber of existence reviews and prognostic elements also are thought of. After comparing the most recent technological and organic advances, together with IMRT, IMAT, cyber knife therapy, and tomotherapy, the publication concludes by means of thorough attention of particular points of scientific learn in lung melanoma.

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Extra resources for Advances in Radiation Oncology in Lung Cancer

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J Neurosci Res 85:3523–3529 Loriot Y, Mordant P, Deutsch E (2009) Are RAS mutations predictive markers of resistance to standard chemotherapy? Nat Rev Clin Oncol 6:528–534 Ma PC, Jagadeeswaran R, Jagadeesh S et al (2005) Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 65:1479–1488 Ma PC, Tretiakova MS, Nallasura V et al (2007) Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion.

Since MVD by definition measures the peak vessel density, use of small samples may affect accuracy and it is technically difficult to sample similar areas of 21 tumor repeatedly. Secondly, while MVD reflects some aspects of the angiogenic process, it may not be a measure of the relative dependence of a particular tumor on angiogenesis, and changes in MVD do not necessarily correlate with changes in tumor growth rate. The expression level of angiogenic factors, either quantified within tumor tissue or after secretion into body fluids, provides another indirect measure of tumor angiogenesis.

Cell 141:69–80 Shimizu E, Coxon A, Otterson GA et al (1994) RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 9:2441–2448 Sibilia M, Wagner EF (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234–238 Soda M, Choi YL, Enomoto M, Takada S et al (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448:561–566 Soda M, Takada S, Takeuchi K et al (2008) A mouse model for EML4-ALK-positive lung cancer.

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Advances in Radiation Oncology in Lung Cancer by Dusan Milanovic (auth.), Branislav Jeremic (eds.)


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