By Paul H. Sugarbaker MD, FACS, FRCS (auth.), Santiago González-Moreno MD, PhD (eds.)
S. González-Moreno (Ed. ) Advances in Peritoneal floor Oncology With forty five Figures in fifty seven Separate Illustrations, 12 in colour and 19 Tables 123 IV Preface Santiago González-Moreno, MD, PhD division of Surgical Oncology Centro Oncológico MD Anderson foreign España Calle Gómez Hemans 2 28033 Madrid Spain sgonzalez@mdanderson. es Library of Congress keep an eye on quantity: 2006937141 ISSN 0080-0015 ISBN 978-3-540-30759-4 Springer Berlin Heidelberg long island This paintings is topic to copyright. All rights are reserved, no matter if the full or a part of the fabric is worried, speci? ?cally the rights of translation, reprinting, reuse of illustrations, recitations, broadcasting, copy on micro? ?lm or in the other manner, and garage in facts banks. Duplication of this e-book or components thereof is authorized in basic terms below the provisions of the German Copyright legislation of September nine, 1965, in its present model, and permission to be used should always be acquired from Springer-Verlag. Violations are chargeable for prosecution less than the German Copyright legislations. Springer is a part of Springer Science+Business Media http//www. springer. com Springer-Verlag Berlin Heidelberg 2007 revealed in Germany using normal descriptive names, emblems, and so forth. during this ebook doesn't suggest, even within the absence of a speci? ?c sta- ment, that such names are exempt from the correct protecting legislation and laws and hence unfastened for common use. Product legal responsibility: The publishers can't warrantly the accuracy of any information regarding dosage and alertness contained during this ebook. In each case the consumer needs to fee such info by means of consulting the correct literature.
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Kawamura et al. reported that a highly metastatic cell line on the peritoneum overexpresses integrin α1, α2, and β1 . Furthermore, neutralizing antibody for integrin α1, α2, and β1 subunits can inhibit the adhesion of cancer cells to the peritoneum. These results suggest integrins as target molecules to consider in research for the prevention of peritoneal dissemination. Furthermore, complementary DNA microarray and histochemical analyses revealed differences in the concerted expressions of several genes coding for matrix proteinases, cell adhesion, motility, angiogenesis, and proliferation between the highly metastatic and parental cell lines .
Whilst there is, therefore, an increasing burden on the pathologist to identify and classify these tumours appropriately, a significant confounding factor is the fact that there is a spectrum of mucinous tumours rather than rigid categories. The term pseudomyxoma peritonei (PP) is a description of a clinico-pathological entity  in which there is mucinous ascites and mucinous implants in the peritoneum that may, or may not, contain epithelial cells . The spectrum of disease ranges from mucinous ascites (free acellular mucin in the peritoneal cavity), through organising mucinous fluid (mucin containing fibroblasts, capillaries, inflammatory cells and mesothelial cells) and disseminated peritoneal adenomucinosis (mucin with scanty simple to focally proliferative muci- 32 nous epithelium with little cytological atypia or mitoses) through to peritoneal mucinous carcinomatosis (pools of mucin within which there are abundant malignant epithelial cells with either cytological or architectural features of malignancy).
We have also argued [6, 14] that, on the antimesenteric aspect of the colon, that the serosal surface is very close to the outer muscular layer, with often <5 mm between them. Thus, as about 95% of all colonic cancers have fully penetrated the latter, it is not surprising, to us at least, that about half of them, perhaps especially those tumours which are either circumferential or show a large anti-mesenteric component, have spread just that short distance further and have infiltrated and ulcerated the serosa.
Advances in Peritoneal Surface Oncology by Paul H. Sugarbaker MD, FACS, FRCS (auth.), Santiago González-Moreno MD, PhD (eds.)