By P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)
P. Denoix and G. Mathe nearly 70% of melanoma sufferers relapse after surgical procedure earlier than the fifth yr and, quite often, for instance in breast carcinoma, they relapse nonetheless later as much as the twentieth 12 months. For a few enormous time, the tactic of melanoma therapy has been constrained to the sophistication of surgery-radiotherapy combos that maximally reduced the occurrence of neighborhood and local relapses in websites that have been inside of their succeed in. at the present time, the perform of medical oncology is unthinkable with no the energetic participation of the clinical oncologist. he's the "third guy" of the medical oncology crew, and he has lately centred recognition at the incontrovertible fact that such a lot relapses come up from far away metastases as a result of the proliferation of cells seeded there after having left the first tumor website on the time of operation and, as a result, are inaccessible to any shape oflocal and/or local remedy. in this facts, scientific oncologists have proposed the applying of scientific remedies for disseminated minimum residual disorder (MRD). they've got on hand capacity: chemother apy and immunotherapy. clinical oncologists mostly will be divided into 3 teams: chemotherapists, immunotherapists, and chemoimmunotherapists. The natural chemotherapists, who had already cured a few malignant neoplasias reminiscent of Hodgkin's ailment, acute lymphoid leukemia, placental choriocarcinoma, and Wilms' tumor, suggestion they could have the technique of attacking the residual affliction of universal cancers.
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A test for aFP was positive but we do not known the exact level. Ten and 20 days after surgery, the aFP concentration had decreased to 120 and 65 ng/mI, respectively; but by day 40 the aFP level had increased to 75 ng/mI. This rise signified a recurrence (Fig. 5), which was rapidly confirmed. The boy underwent further surgery and curettage of a lymph gland was performed, after which the aFP level became normal. D. Buffe and C. Rimbaut 36 lXFP ng/ml 10 6 +1 5t Operation \• +2nd Operation \ A-\------ ----- \------- - !
HMW ACTH has been shown to be a glycopeptide on the basis of concanavallin A affinity chromatography ; 5. ACTH, j3-LPH, y-LPH, j3-END, and a HMW component with both ACTH and LPH immunoreactivity have been demonstrated in an extract of a pancreatic islet cell carcinoma . However, there has been no human model system analogous to the AtT-20/D-16v cell line in which to examine the biosynthetic relationships of these peptide products. We have studied the secretion products of human cancer cells derived from an oat cell carcinoma of the lung (DMS-79).
14, 3-18 (1973) 8. O'Connor, G. , Tatarinov, Y. : A collaborative study for the evaluation of a serologic test for primary liver cancer. Cancer 25, 1091-1095 (1970) 9. , Caillaud, J. : Alpha-l-fetoprotein (AFP) and Germ Cell Tumors: Biological and Histological Correlation. 5th IRGCP Meeting of Int. Research Group for carcinoembryonic proteins "recent progress". Copenhagen, August (1977) (in press Scand. J. Immunol. 7, Suppl. 8 (1978» 10. Smith, T. : Alpha fetoprotein: occurence in certain malignant diseases and review of clinical applications.
Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies by P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)