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5. Chloramphenicol exposure can cause gray baby syndrome. 6. Aminopterin and its derivative methotrexate, antitumor agents and folic acid antagonists, cause anomalies including: a. Skeletal defects b. Anencephaly, hydrocephalus c. Cleft lip and palate d. Abortion 7. Antithyroid drugs (thiouracil, iodides, radioactive iodine) can cause goiter. 8. Environmental chemicals, such as organic mercury present in fish from polluted waters or certain fungicides sprayed on grain, cause anomalies including neurologic symptoms resembling cerebral palsy and blindness.

Maternal diabetes. Abnormal changes in the carbohydrate metabolism of the mother is often the cause of abortions, stillbirths, neonatal deaths, and abnormally large infants. 2. Maternal iodine deficiency causes cretinism. iiiii&ical 4s sEcTroN il Histology Epithelial tissue consists of a variety of celltypes with a minimal amount of extracellular material, which together line and cover virtually all free surfaces of the body. Epithelia are derived from all three germ layers and form sheets composed of groups of cells, in one or more layers, joined by specialized adhesions.

The Barr body is usually present only in normal females. 5. Turner syndrome (XO) or ovarian dysgenesis a. This syndrome is characterized by the absence of ovaries, dysmenorrhea, and infantile external genitalia and mammary glands. b. No sex chromatin is present. c. Turner syndrome is often associated with short stature, webbed neck, lymphedema of the extremities, skeletal defects, no or mild mental retardation, and congenital heart defects. B. Structural chromosomal abnormalities are usually due to chromosomal breakage caused by environmental factors.

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